3D bioprinted cell culture models

Traditional in vitro culture models are unable to fully reflect the organ microenvironment owing to the difference in terms of cell morphology, protein expression, cell–cell and cell–matrix interactions, and drug response. By contrast, the flexibility of bioprinting models allows deposition of biomaterial–cell spheroid–tissue in any free-form-inspired complicated 3D structures on the chip, creating cell culture models tailored for studying cell–cell and cell–matrix interactions. Our group is interested to use this technology in the contest of personalized medicine, to culture patient derived primary cells, in order to test directly in vitro the efficacy of the available drugs for a specific disease.